643 Grand Avenue, South San Francisco, CA 94080

• 3 beds |
• 4 baths |
• 1,630 sqft

Property Description

Ideally located near Downtown South San Francisco and the cities thriving biotech and life-sciences corridor, 643 Grand Avenue where space, comfort, and a remarkable garden setting come together in the heart of South San Francisco. 643 Grand Avenue offers a spacious and versatile layout with excellent access to major transportation and employment centers. The home features 3 bedrooms and 4 bathrooms, with a private full bathroom for each bedroom. Additional highlights include high ceilings, abundant natural light, hardwood floors, a full basement with ample storage, and a detached 2-car garage equipped with a 220-volt outlet for EV charging and an additional 2 car off street parking in front of the house. The home also features a water purification system, tankless water heater, and water softener. The quaint lot includes a freshly manicured organic vegetable garden with sunflowers and offers potential for an ADU. Conveniently located near Downtown South San Francisco, Genentech, Caltrain, US-101, and I-280.

Listing Status:

Active

Date Added:

August 28, 2026

Data Last Updated:

October 9, 2026 at 7:06AM

Listing Office:

Christie's International Real Estate Sereno :

Listing Agent:

Jill Penna : 415-244-8630

MLS ID:

ML82059314

Interior

• Appliances: DishwasherWater Softener
• Flooring: Hardwood
• A/C: None
• Heating: Forced Air

Construction

• General: 2Slab

Location

• School District: South San Francisco Unified
• County: San Mateo

Lot

• Zoning: RM00012241120

Utilities

• Water: Public
• Sewer: Public Sewer