422 21st Street, Denver, CO 80205

• 4 beds |
• 2 baths |
• 6,565 sqft

Property Description

Located in the heart of Five Points, this unique for-sale offering presents a compelling investment, owner-user, or redevelopment opportunity on a highly visible 6,270 SF corner lot just steps from Downtown Denver, Uptown, and the vibrant Five Points district. The property consists of a well-maintained single-family home and an adjacent office duplex, providing multiple income streams and flexible future potential. The approximately 2,565 SF single-family residence features four bedrooms and two bathrooms and is most recently operated as a successful Airbnb, offering immediate short-term rental income or the option for an owner-user residence. The office duplex is comprised of two office units of approximately 2,000 SF each, both tenant-occupied on month-to-month leases, allowing for steady income with near-term flexibility for repositioning or redevelopment. With its premier corner location, walkability to Denver’s central business district, and proximity to restaurants, nightlife, transit, and cultural amenities, this property offers exceptional upside in one of Denver’s most dynamic and rapidly evolving neighborhoods.

Listing Status:

Active

Data Last Updated:

February 15, 2026 at 7:19AM

Listing Office:

Kentwood Commercial, Llc : 303-773-3399

Listing Agent:

Karen Zeile : 303-947-3665

MLS ID:

6487194

Interior

• A/C: None
• Heating: Hot Water

Exterior

• Parking: Parking spaces: 0

Construction

• Roofing: Composition
• General: Two

Location

• Originating MLS: recolorado
• School District: Denver 1
• County: Denver

Lot

• Zoning: C-MX-5CLEMENTS ADD B191 L1 & 22341-27-015

Utilities

• Sewer: Public Sewer

Financial

• Source: recolorado
• Ownership: Individual
• Exclusions: Personal Property.