1250 MCDUFF Avenue S, Jacksonville, FL 32205

• 2 beds |
• 2 baths |
• 2,800 sqft

Property Description

Located in the heart of Jacksonville's vibrant Riverside Avondale Historic District, this versatile mixed-use property at 1250 McDuff Avenue South offers a rare opportunity to live, work, or invest in one of the city's most walkable and sought-after neighborhoods. The first floor commercial space spans approximately 1,800 square feet and allows a wide range of uses by right, including medical or professional office, retail sales, service establishments, and restaurant use—making it ideal for owner-operators or investors seeking flexible income potential. Commercial Neighborhood zoning is scarce in Riverside Avondale, with only three small areas—less than 35 properties total—making this a highly desirable location to operate a business. Upstairs, the residential unit is a charming 2 bedroom, 1 bathroom apartment of roughly 1,100 square feet, featuring hardwood floors and a charming midcentury bathroom that adds character and warmth. The layout is well suited for an owner-occupant, employee housing, or long-term rental. The location creates for a high rental value as it is within walking distance to the Avondale and King Street Shopping Districts, the Riverside Community Garden, Willowbranch Park, and the St. Johns River. Both the commercial and residential spaces were leased to long-term tenants at below-market rents, presenting clear upside for future value. Whether you envision a live/work setup, renting one space to offset expenses, or holding the property as a pure investment, the options here are compelling. While located within the historic district, the building itself is not a contributing structure, offering added flexibility for future use. Take advantage of this rare opportunity for a mixed-use property in one of the most desirable neighborhoods in Jacksonville. Note: This property is also listed as Residential MLS #2129351 and Commercial MLS #2129365

Listing Status:

Active

Date Added:

February 9, 2026

Data Last Updated:

February 13, 2026 at 7:36PM

Listing Office:

COWFORD REALTY & DESIGN LLC : 904-330-4733

Listing Agent:

CARMEN GODWIN : 904-708-0825

MLS ID:

2129340

Interior

• Appliances: DryerElectric RangeElectric Water HeaterRefrigeratorWasher
• Laundry: In Garage
• Flooring: ConcreteLaminateTileWood
• A/C: Central Air
• Heating:

Construction

• Roofing: Shingle
• General: Wood SidingBrickTwo

Location

• Road/Access: City Street
• Originating MLS: realMLS (Northeast Florida Multiple Listing Service)
• County: Duval

Lot

• Zoning: 0781240000
• Current Use: CommercialMixed UseResidential

Utilities

• Utilities: Cable AvailableElectricity AvailableSewer AvailableWater Available
• Water: Public
• Sewer: Public Sewer

Financial

• Source: realMLS (Northeast Florida Multiple Listing Service)